MAV(S)erick mitochondria: an unconventional role for mitochondrial antiviral signalling protein in pulmonary fibrosis

نویسندگان

چکیده

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, age-related interstitial lung disease. Incidence of IPF in the USA ranges between 14 and 63 per 100 000 people [1]. The average survival rate from time diagnosis 3–5 years. associated with several genetic environmental factors. Genes risk for developing generally fall into two categories: epithelial cell genes ( e.g. MUC5B , DSP SFTPA2 ABCA3 ) or involved telomere maintenance TERT TERC RTEL1 [2, 3]. Mitochondrial antiviral signalling protein (MAVS) mediates by regulating cGAS-STING senescence programming

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ژورنال

عنوان ژورنال: The European respiratory journal

سال: 2021

ISSN: ['0903-1936', '1399-3003']

DOI: https://doi.org/10.1183/13993003.04500-2020